Top 10 Nitric Oxide Supplements

Did you know that almost every cell in your body produces Nitric Oxide? Scientific research has shown that virtually every known human cell produces nitric oxide naturally. This explains the significant role that this compound plays in your body and shows why you need supplements to ensure it is always abundant in your body. The type of supplements needed should contain L-arginine and L-citrulline.

NO is a vital compound required in the body for the proper functioning of the circulatory system. The compound ensures that blood vessels such as capillaries, veins, and arteries widen, which stimulates the manufacture of vital hormones such as human growth hormones and insulin.

These supplements are popular due to their health benefits. They contain the oxide and other essential nutrients that are required for the proper functioning of the human body.

The Top 10 Nitric Oxide Supplements

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1) Blackstone Labs Hype Reloaded

Overview: New from Blackstone Labs is the latest formulation of their Hype Pre-Workout, called Hype Reloaded. This is a stimulant free, Pre-Workout that is different from anything else you’ll find online or in your favorite supplement store. This super formula is designed to give you major muscle pumps and vascularity.


Ingredients: Citrulline Malate, Glycerol Monostearate, Alpha GPC 300mg, Icariin Horny Goat Weed, Potassium, L-Norvaline


Conclusion: Offered in 4 flavors, this top tier Nitric Oxide supplement promises skin splitting pumps, increased cell volume and vascularity, all without caffeine and other stimulants.


hype reloaded nitric oxide

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2) Cellucor NO3 Chrome

Overview: NO3 Chrome is a stimulant and creatine free nitric oxide supplement designed to provide increased blood flow bigger pumps. NO3 Chrome utilizes Arginine Nitrate which is a combination of L-Arginine and Nitrate for your best workout results.


Ingredients:Vitamin C, Calcium, Arginine Nitrate, Nitrosigine® Inositol-Stabilized Arginine Silicate, Citrulline Malate, Grape Seed Extract


Conclusion: Cellucor is a trusted name in the industry and this product is a quality Nitric Oxide supplement. Chrome comes in capsule form so its more convenient than scooping powder.



cellucor chrome NO3 bottle

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2) M3 Miracle Molecule Max

Overview: M3 combines Arginine + Citrulline with Beetroot and antioxidants to give your body what it needs to support cardiovascular health. This supplement has a 3 stage effect with l-arginine absorption at one stage, l-citrulline in the second and finally, beet root in the last stage. Combine all that with antioxidants and herbal ingredients and you get a sustained release boost of energy throughout the day.


Ingredients:L Arginine AKG, L-Citruline, Beet, Watermelon, Blackberry, Raspberry, Hawthorn Berry, Horse Chestnut, Green Coffee Bean, Indian Gooseberry, Grape Seed Extract, Vitamin D3, Camu Camu Berry, AstraGin, Vitamin C


Conclusion: This quality supplement was designed by doctors and has a 2:1 Arginine to Citrulline ratio. It has a perfect 5 star rating  in more than 300 Amazon reviews.


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How Nitric Oxide Supplements Work in your Body:

Although these supplements are rich in different nutrients, they are mostly composed of L-citrulline and L-arginine. L-citrulline is an essential amino acid found in protein-rich foods such as meat, legumes, nuts, and fruits such as watermelon.

L-arginine is also an amino acid that is considered a body building block. It naturally occurs in animal products that are rich in proteins such as poultry products, dairy products, red meat, and fish.

Although one can opt to take these foods in large numbers to derive the benefits of these compounds, it is now common for people to take supplements as a ready source of L-arginine and L-citrulline.

According to research featured in The Journal of Nutrition, an adult human being consumes about 5 grams of L-arginine daily, which is not sufficient to meet the body’s requirements. The study underpins the importance of the supplements in meeting the deficiency.


Health Benefits of Nitric Oxide Supplements:

Different scientific researchers have outlined the benefits of these supplements in the human body. Some of the researched benefits of this compound in the body are:

1. It improves heart health:

It has numerous health benefits that ensure the proper functioning of the human body’s cardiovascular system. According to an article that was featured in the Biochemical and Biophysical Research Communications Journal, these supplements boost the functioning of the heart and other organs of the circulatory system.

The compound achieves this by reducing blood pressure, managing the arterial stiffness, and enhancing the carotid artery blood flow. It is important to point out that the researchers used animal specimens to come up with their conclusions.

2. The supplements promote working out and recovery.

Studies have proved that this oxide enhances the proper functioning of the circulatory system by promoting the delivery of oxygen to body muscles. Scientists, therefore, hypothesize that it will also play a significant role in strengthening the body and boosting its recovery after exercise.

A study published in the Sports Medicine Journal showed that these supplements could also enhance a person’s endurance. The study also showed that the presence of NO in the body improves tolerance during exercise. The researchers, therefore, concluded that athletes could use the supplements to enhance their endurance and improve performance.

3. They help reduce erectile dysfunction.

Erectile dysfunction is associated with reduced blood flow to the penis. Scientific research has shown that because the supplement boosts the human blood circulatory system’s functioning, it could also address the condition of erectile dysfunction (ED).

Research published in the Future Science OA Journal indicates that there is significant scientific evidence that the supplements could help men reverse mild or moderate ED.

4. The supplement helps reduce high blood pressure.

Scientific research has shown that the supplements can help address specific forms of high blood pressure, especially preeclampsia. This is a form of high blood pressure that develops in women during pregnancy. If not brought under control, the condition can be fatal to both the woman and the baby.

A study conducted in 2005 and results published in the European Journal of Clinical Investigationfound out that if pregnant women used L-arginine supplements for an extended period, there was a significant drop in their pressure as compared to those who did not take it.

It is imperative to note, however, that more research is still needed in this regard. This is because conclusions were drawn from preliminary results that linked the supplements to reduced blood pressure in pregnant women.

Potential Side Effects of Using these Supplements:

Scientific research has shown that the supplements do not pose any scientific side effects in most people who use them. In fact, only a few people have suffered side effects of any kind. In most cases, however, the side effects are mild and may include:

Stomach pain
Heart palpitations

Who Should Not Use these Supplements?

Although this supplement is safe and does not pose any danger to many people, it is not advisable for the following people to use it:

People diagnosed with liver cirrhosis. If you have the cirrhosis condition, you should seek the guidance of your doctor before using NO supplements. This is because the might inhibit the proper functioning of your liver.

Individuals with low blood pressure. The supplement widens the blood vessels, thus reducing blood pressure. It is not recommended, therefore, for people with low blood pressure since the condition might worsen. This means that you should also stop using the supplements if you are scheduled to undergo a surgery.

Guanidinoacetate methyltransferase deficiency. It is a genetic condition that is rare. It occurs if an individual lacks enzymes necessary in the conversion of arginine into creatine (waste).


These supplements contain two main components: L-arginine and L-citrulline. Although they have been in use for many years, there has been limited research on their effectiveness. Recent studies, however, have showed positive results in boosting the functioning of the circulatory system by widening the blood vessels and managing high blood pressure in human beings.

Other health benefits of these supplements include managing erectile dysfunction, enhancing the heart’s functioning, and increasing body recovery after exercise. These supplements are generally safe to human beings, although it is not recommended for people with conditions such as low blood pressure and liver cirrhosis. Anyone with such conditions should seek medical guidance before using these supplements.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition. We offer no medical advice. Always consult your physician before taking supplements or engaging in an exercise program.

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